Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
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چکیده
منابع مشابه
Active and Passive Immunization Strategies for Protection of Mice and Monkeys against Orthopoxvirus Infection
Title of Document: ACTIVE AND PASSIVE IMMUNIZATION STRATEGIES FOR PROTECTION OF MICE AND MONKEYS AGAINST ORTHOPOXVIRUS INFECTION. Christiana Nichols Fogg, Ph.D., 2006 Directed By: Dr. Bernard Moss, Adjunct Professor, Department of Cell Biology and Molecular Genetics The Poxviridae are large DNA viruses that replicate in the cytoplasm of vertebrates or invertebrates. The genus Orthopoxvirus incl...
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Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab')2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication. Similar ricin-binding affinities and neutralizing activities in vitro were observed between IgG and F(ab')2 when compared at the same molar conc...
متن کاملLateral flow urine lipoarabinomannan assay for detecting active tuberculosis in Hiv-positive adults
BACKGROUND Rapid detection of tuberculosis (TB) among people living with human immunodeficiency virus (HIV) is a global health priority. HIV-associated TB may have different clinical presentations and is challenging to diagnose. Conventional sputum tests have reduced sensitivity in HIV-positive individuals, who have higher rates of extrapulmonary TB compared with HIV-negative individuals. The l...
متن کاملQuest for correlates of protection against tuberculosis.
A major impediment to tuberculosis (TB) vaccine development is the lack of reliable correlates of immune protection or biomarkers that would predict vaccine efficacy. Gamma interferon (IFN-γ) produced by CD4(+) T cells and, recently, multifunctional CD4(+) T cells secreting IFN-γ, tumor necrosis factor (TNF), and interleukin-2 (IL-2) have been used in vaccine studies as a measurable immune para...
متن کاملA Sensitive Urinary Lipoarabinomannan Test for Tuberculosis
We have previously developed a diagnostic test for tuberculosis based on detection of mycobacterial lipoarabinomannan (LAM) in urine. The method depended on a laborious concentration step. We have now developed an easy to perform test based on a magnetic immunoassay platform, utilizing high avidity monoclonal antibodies for the detection of LAM in urine. With this method the analytical sensitiv...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.01968